Neem de-oiled cake (DOC) is a versatile by-product of neem oil extraction from neem tree seeds (Azadirachta indica), with applications in agriculture, environment management, and industry. It serves as an organic fertilizer rich in essential nutrients like nitrogen, phosphorus, and potassium, enhancing soil fertility and promoting plant growth. Additionally, it acts as a natural pesticide against soil-borne pests, supports soil health by increasing organic matter, and is utilized in biogas production and composting, contributing to sustainable farming practices and environmental conservation.